pdf Evaluation of Serum Immunoglobulins IgM, IgG, Interleukins IL-33 and IL-37 in Women Infected with Trichomonas Vaginalis

Noor Ghassan Kazem Jaber Al-Dulaimi, Maha Falih Nazzal and Ibtisam Badday Hassan

Abstract

During infection with Trichomonas vaginalis, immune cells, antimicrobial peptides, cytokines, chemokines, and adaptive immunity evolve in the reproductive tract, and a pro-inflammatory response is generated to eliminate this invading extracellular pathogen. 

This case-control study aimed to evaluate some immunologic parameters (IgM, IgG,Il-33, IL-37) in women infected with Trichomonas vaginalis parasite.

The current study was conducted on (45) women with Trichomoniasis who visited Al-Batoul Teaching Hospital and private gynecology clinics in Baqubah, Diyala Governorate, during the period from November 2023 to July 2024. The study also included (45) healthy uninfected women as a control group. Estimation the levels of immunoglobulins IgM, IgG and interleukins IL-33, IL-37 were carried out using the Enzyme linked immuno sorbent assay technique (ELISA).

There was a highly significant increase in the (mean±SD) of IgM and IgG in women with Trichomoniasis (2.09±0.77) and (14.32±6.67) respectively compared to the mean ±SD of these antibodies in healthy women (0.07±0.12) and (0.23±0.13) respectively (p=0.00). The results showed that there was a highly significant increase in the mean ±SD of IL-33 and IL-37 in women with trichomoniasis (13.85±2.41) and (14.29±1.85) respectively compared to the mean±SD of these interleukins in healthy women (0.56±0.73) and (7.35±1.19) respectively (p=0.00).

It can be concluded from the current study that there was a highly significant increase in the levels of IgM, IgG, IL-33 and IL-37 in women infected with trichomoniasis.