pdf Physiological and Immunological Variations between Alfa and Beta Male Thalassemia in Baghdad.

Maliah H. Hamel, Asmaa H. juma and Mousa M. Marbut

Abstract

Βeta thalassemia, which is characterized by impaired beta globin chain synthesis. β-thalassemia major, A severe anemia with ineffective red blood cell production that can be life-threatening. Interleukin-6 had been reported to elevate in βeta Thalassemia patients and this may be due to multiple Hemotransfusion. This study aims to investigate the roles of blood ferritin, IL-6 & IFN- γ in Beta Thalassemia Major individuals as compare with α-thalassemia patients. Patients and methods; Eighty male subjects were participated in the present study, (20 male patients with Beta thalassemia, 20 male patients with alfa thalassemia and 40 male normal healthy subjects. The work was done in Al-baldy hospital in Baghdad from beginning of December 26, 2023 to the end of April 2024. Blood samples were taken from all patients. Hematological, IL-6 and IFN- γ were measured.

 There is a highly significant increase in ferritin levels of β-thalassemia patients as compare with α-thalassemia cases. Also, a substantial increase is observed (p≤0.01) in the IL-6 level of β-thalassaemia major patients, as compared with α thalassemia patients.