The Impact of Pregnancy Associated Plasma Protein-A (PAPP-A) on Live and Dead Embryos at Various Developmental Stages

Abstract

Pregnancy Associated Placental Protein A (PAPP-A) is Zinc-Binding metalloproteinase with a vital role in insulin like growth factor (IGF) pathway. IGF system plays a key role in follicular development, including steroid hormone synthesis, growth, recruitment, and apoptosis of follicles. There is minimal information in the literature regarding PAPP-A levels in Follicular Fluid (FF) of women that undergoing intra-cytoplasmic sperm injection (ICSI). The purpose of study to detect PAPP-A in blood and follicular fluid during oocyte pick up in infertile women undergoing ICSI, and to investigate the role of PAPP-A in embryonic development. The findings showed a nonsignificant relationship between total oocyte number and oocyte maturity and serum and FF PAPP-A, and fertilization rate. There was a significant correlation between live and dead embryos with different embryonic stages. There was a non-significant correlation between serum and FF PAPP-A with total, mature, and fertilized oocytes, and the oocyte quality parameters examined in this study (total oocyte, mature oocyte, and fertilized oocyte) were influenced by numerous factors (age, prior pregnancies, weight, and others). Live and the dead embryo was not-significant in the embryonic stages (two-cell stage, four-cell stage, and eight-cell stage embryos), except two cell stage dead embryo with serum PAPP-A and four-cell stage dead embryo with FF PAPP-A was high significant differences.