A Biochemical Analysis for Glucose homeostasis regulated by certain hormones

Abstract

         The aim of this study was performed to compare ghrelin and GLP-1 levels in individuals with normal blood sugar levels. This study was performed to compare ghrelin and Glucagon like peptide -1 (GLP-1) levels in individuals with normal blood sugar levels. Participants and methods: The study included a total of 200 individuals, with 58% of being male. The mean age of the participants was 37.2 ±4.2 years. BMI mean was 31.9 ±4.4 kg/m². The subjects were tested in a condition of fasting, as well as 30 and 60 minutes after ingesting a standard liquid meal. Throughout this testing, we evaluated the concentrations of ghrelin and GLP-1. Results: Patients exhibited the most unfavorable metabolic profile, defined by higher levels of glucose. It was noted that the levels GLP-1 and insulin exhibited a similar increase in all groups after consuming a standard meal, regardless of whether the participants were fasting or had eaten 30- or 60-minutes prior. Glucose levels exhibited a rise in all groups following the consumption of food. However, the rise was significantly more pronounced in the DOB group as compared to the NOB as well as CON groups at the 30 and 60-minute marks after the meal (p < 0.00). Conclusion: It has been concluded that GLP-1 and ghrelin levels in individuals with different levels of glucose tolerance had similar responses after consuming a typical liquid meal.