Immunohistochemical Expression of the Estrogen Receptor in Oral Pemphigus Vulgaris

Abstract

The current study sought to assess the immunohistochemical expression of estrogen receptors (ER-α) in oral PV biopsies. The study was conducted from May 10, 2020, to February 9, 2021. 44 paraffin embedded oral PV tissue blocks were taken. Each block was sliced with a microtome. Antibodies were applied to each sample using the IHC technique to observe the expression of ER. The first was dependent on the intensity of the stain, and the second on the percentage of cells with positive stain. All results were statistically analyzed using the SPSS application. The Chi-square and Spearman tests were used. Results: The intensity of ER-α in all silds was studied and found to be negative in 29 cases and mild in 15 cases. According to the percentage of the cells with positive stains, the results were as follows: The 30 cases registered as negative for ER-α, the scoring for 11 cases was weak, and finally 3 cases showed a moderate score. The current study showed that activation of ER- doesn't play a role in the story of PV, but more research was needed to figure out and clarify the role of EH in autoimmune blistering conditions.