pdf Evaluation of Some Cytokines in Patients Have Toxoplama Gondii Association with Hepatitis C Virus Infections

Abstract

Five ml of venous blood samples were collected from a group of 100 individuals diagnosed with Hepatitis C virus (HCV) infection, along with a control group comprising 50 healthy individuals. The sample collection was conducted from Ibn Al-Balady Children & Maternity Hospital. This process spanned from May 2024 to the end of September 2024. The results showed, in the context of our study on Hepatitis C Virus (HCV) and its potential co-infection with Toxoplasmosis, This cohort comprised 100 patients diagnosed with HCV, including 20 who were also co-infected with Toxoplasmosis. The gender and age distribution within this group provided insightful data for our analysis, with 52 males and 48 females ranging from 5 to 65 years. Additionally, for comparative purposes, we included a control group of 50 healthy individuals, balanced in gender (25 males and 25 females) and ranging in age from 5 to 50 years. The demographic data of these participants is crucial for understanding the impact and prevalence of these infections across different segments of the population. The distribution of IL-32, IL-33, and TNF-α among the study groups is thoroughly detailed in Table 4-4 and Figure 4-3. A striking difference is observed in the levels of these cytokines between the control group and the patient group. For IL-32, the control group's mean level was 3.919 with a SE of 0.226. This significantly contrasts with the patient group, which exhibited a much higher mean of 10.428 and a SE of 0.242. The difference in IL-32 levels between the two groups was highly significant, marked by a p-value less than 0.001. Similarly, IL-33 levels showed a substantial disparity. The control group had a mean of 4.775 and a SE of 0.249, whereas the patient group had a notably higher mean of 24.213 and a SE of 0.839. This difference was also highly significant, with a p-value less than 0.001. Lastly, the TNF-α levels followed a similar pattern. The mean level in the control group was 4.655 with a SE of 0.271, compared to the patient group, which had a significantly higher mean of 14.588 and a SE of 0.849. This difference, like the others, was highly significant, indicated by a p-value of less than 0.001.