Impact of Granulation Parameters on the Porosity and Disintegration Time of HPMC Granules Prepared by Fluidized Bed Technique
DOI:
https://doi.org/10.65204/djes.v3i2.758Keywords:
Fluidized bed granulation , HPMC, Porosity, Disintegration, Design-Expert 13Abstract
Fluidized bed granulation is widely applied in several industrial sectors. The present study examines how key process parameters ( air flow rate, liquid-to-solid (L/S) ratio, granulation time, and feed mass) affect the porosity and disintegration time of (HPMC) granules. Experiments were carried out using A lab-scale, top-spray fluidized bed granulator and a full factorial experimental design was employed and analyzed both the individual and interactive effects of the selected variables. The findings show that an increase in feed mass resulted in higher bed porosity, while higher airflow rates tended to decrease porosity. The increased in feed mass likely promoted the formation of larger, less densely packed agglomeration. The L/S ratio and granulation time showed a major interactive effect, with higher levels promoting structural consolidation and reduced porosity. Disintegration time was primarily prolonged by higher L/S ratios, whereas increased granule porosity facilitated faster liquid penetration and shorter disintegration time.
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